AMML - Slide 1

Acute myelomonocytic leukemia with an impressive display of cells with a predominant promonocytic morphology, accompanied by a leukocytosis of

132⋅10⁹/L

. Formally, promonocytes are not blast cells, but they are counted as blasts for the diagnosis of acute leukemia (>20% blasts in peripheral blood). Immunophenotyping reveals an AML with monocytic characteristics.

Blasts

Promyelocytes

Bands

Segments

Lymphocytes

Immunophenotype

CD34-

CD117-

CD13+

CD33+

HLA-DR+

CD11c+

CD14-

CD64+

The divergent population is positive for the monocytic markers CD11c and CD64. In addition, a seperate population of CD14 positive cells can be seen, which indicates more mature monocytes (arrow).

SSC

CD45

CD117

CD34

HLA-DR

CD64

CD13+CD33

CD14

CD15

CD16

CD64

CD11c

Peripheral blood

Blasts