Beta-Thalassemia - Slide 1
A homozygous beta-thalassemia with secondary hemochromatosis. A lot of abnormalities of the red cell lineage can be seen; schistocytes, teardrop cells, microcytic and macrocytic cells, basophilic stippling and hypochromic erythrocytes. In addition, this patient has a massive production of erythroblasts. Because of this homozygous presentation, the patient is transfusion-dependent and receives two units of blood every 5 weeks.
The hemoglobin of this patient was
4.6 mmol/L
, with an MCV of 85 fL
and an RDW of 21%
. The number of erythrocytes was low at 2.8⋅1012/L
. The number of erythroblasts was 83 promille. Due to the chronic blood transfusions, the patient has an iron overload which is seen as a ferritin of 5600 µg/L
.XN Scatterplots
Peripheral blood

Erythroblasts























